Dr. David Filgueiras Rama

Medico Especialista de Área (desde Junio 2008). Ambito de trabajo: UNIDAD DE ELECTROFISIOLOGÍA Y ARRITMIAS (Hospital Clínico San Carlos)

Jefe de Grupo/Investigador (Dede 2013). Department Advanced Development in Arrhythmia Mechanisms and Therapy. Spanish Cardiovascular Research Center (CNIC)

Education

CV SUMMARY

I have a background in basic and clinical cardiac electrophysiology with expertise in research areas related to mechanisms underlying complex cardiac arrhythmias. My research experience started back in 2009 after I completed my clinical cardiology-training programme. Since then may career has been driven by a passion to take my clinical work beyond conventional diagnosis and develop new advanced diagnostic and therapeutic approaches for complex cardiac arrhythmia phenomena. I am especially interested in new therapeutic alternatives and mapping technologies based on deep understanding of cardiac fibrillation. Throughout my research career I have tried to develop new technological tools and turn them into new clinical methods taking advantage of my double position and CNIC and the Arrhythmia Unit of the Hospital Clínico San Carlos. This translational endeavor requires the combination of different experimental skills and a multidisciplinary team that I have implemented in the Advanced Development in Arrhythmia Mechanisms and Therapy laboratory at the CNIC during the last 5 years. This scientific perspective has already provided productive and fruitful collaborations with other national and international investigators, yielding new clinical perspectives in cardiac mapping and treatment of atrial fibrillation.

JCR articles, h Index, thesis supervised…

• Thesis supervised: 4 (ongoing). Master/End of degree Theses supervised (2015-2019): 10/3 respectively.
• Total number of citations: 414 (47 publications in WoS).
• Number of citations during the last five years (2014-2018): 56.2 citations/year.
• Total number of publications in the first quartile (Q1): 43 of the 58 publications have an IF; 29 are in Q1 (67{f5c655f787b2aa1e3818fc57169e64ac11b08833352bcdfb27d7dada25f5ad0e}) and 12 in D1 (28{f5c655f787b2aa1e3818fc57169e64ac11b08833352bcdfb27d7dada25f5ad0e}).
• H-index: Of the total articles published, 78{f5c655f787b2aa1e3818fc57169e64ac11b08833352bcdfb27d7dada25f5ad0e} are original articles and reviews and Dr. Filgueiras is main author in 55{f5c655f787b2aa1e3818fc57169e64ac11b08833352bcdfb27d7dada25f5ad0e} of 1 “Sexsenio” 2011-2016.

RELEVANT MERITS (during the last 5 years)

1. Publications (*Corresponding author, #main author)

1. Quintanilla JG*, Alfonso-Almazán JM, Pérez-Castellano N, Pandit SV, Jalife J, Pérez-Villacastín J, Filgueiras-Rama D*. Instantaneous amplitude and frequency modulations detect the footprint of rotational activity and reveal stable driver regions as targets for persistent atrial fibrillation ablation. Res. 2019; 125:609-627. IF: 15.862 (Q1, D1). Article.
2. José Manuel Alfonso-Almazán, Jorge G. Quintanilla, María Jesús García-Torrent, Santiago Laguna- Castro, Cruz Rodríguez-Bobada, Pablo González, Juan José González-Ferrer, Pablo Salinas, Victoria Cañadas-Godoy, Javier Moreno, Luis Borrego-Bernabé, Nicasio Pérez-Castellano, José Jalife, Julián Perez-Villacastín, David Filgueiras-Rama*. Lesion index titration using contact-force technology enables safe and effective radiofrequency lesion creation at the root of the aorta and pulmonary artery. Circ Arrhythm Electrophysiol. 2019;12:e007080. IF: 4.968 (Q1, D3).
3. Lee P, Quintanilla JG, Alfonso-Almazán JM, Galán-Arriola C, Yan P, Sánchez-González J, Pérez- Castellano N, Pérez-Villacastín J, Ibañez B, Loew LM, Filgueiras-Rama D*. In-Vivo Ratiometric Optical Mapping Enables High-Resolution Cardiac Electrophysiology in Pig Models. Cardiovasc Res. 2019;115:1659-1671. IF: 7.014 (Q1, D1).
4. León DG, López-Yunta M, Alfonso-Almazán JM, Marina-Breysse M, Quintanilla JG, Sánchez- González J, Galán-Arriola C, Castro-Núñez F, González-Ferrer JJ, Ibáñez B, Pérez-Villacastín J, Pérez- Castellano N, Fuster V, Jalife J, Vázquez M, Aguado-Sierra J, Filgueiras-Rama D*. Three-dimensional cardiac fibre disorganization as a novel parameter for ventricular arrhythmia stratification after myocardial infarction. Europace. 2019;21:822-832. IF: 6.100 (Q1, D2).
5. López-Yunta M, León DG, Alfonso-Almazán JM, Marina-Breysse M, Quintanilla JG, Sánchez- González J, Galán-Arriola C, Cañadas-Godoy V, Enríquez-Vázquez D, Torres C, Ibáñez B, Pérez- Villacastín J, Pérez-Castellano N, Jalife J, Vázquez M, Aguado-Sierra J, Filgueiras-Rama D*. Implications of bipolar voltage mapping and magnetic resonance imaging resolution in biventricular scar characterization after myocardial infarction. Europace. 2019;21:163-174. IF: 6.100 (Q1, D2).
6. Calvo D#, Filgueiras-Rama#, Jalife J. Mechanisms and Drug Development in Atrial Fibrillation. Pharmacol Rev. 2018;70:505-525. Review. IF: 18.964 (Q1,D1). #Co-first
7. Peter Lee, Conrado J. Calvo, José M. Alfonso-Almazán, Jorge G. Quintanila, Javier Chorro, Ping Yan, Leslie M. Loew, David Filgueiras-Rama*, José Millet. Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug- Action in Translational Heart Models. Nature Scientific Reports. 2017; 7:43217. IF: 4.259 (Q1, D2).
8. Rivera-Torres J, Calvo CJ, Llach A, Guzmán-Martínez G, Caballero R, González-Gómez C, Jiménez- Borreguero LJ, Guadix JA, Osorio FG, López-Otín C, Herraiz-Martínez A, Cabello N, Vallmitjana A, Benítez R, Gordon LB, Jalife J, Pérez-Pomares JM, Tamargo J, Delpón E, Hove-Madsen L, Filgueiras- Rama D, Andrés V. Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations. Proc Natl Acad Sci U S A. 2016;113(46):E7250-E9. IF: 9.661 (Q1, D1)
9. Lillo-Castellano JM, Marina-Breysse M, Gómez-Gallanti A, Martínez-Ferrer JB, Alzueta J, Pérez- Álvarez L, Alberola A, Fernández-Lozano I, Rodríguez A, Porro R, Anguera I, Fontenla A, González- Ferrer JJ, Cañadas-Godoy V, Pérez-Castellano N, Garófalo D, Salvador-Montañés Ó, Calvo CJ, Quintanilla JG, Peinado R, Mora-Jiménez I, Pérez- Villacastín J, Rojo-Álvarez JL, Filgueiras-Rama D*. Safety threshold of R-wave amplitudes in patients with implantable cardioverter defibrillator. Heart. 2016 Heart. 2016;102:1662-70. IF: 6.059 (Q1, D2).
10. David Filgueiras-Rama*, Conrado J. Calvo, Óscar Salvador-Montañés, Rosalía Cádenas, Jose Ruiz- Cantador, Eduardo Armada, Juan Ramón Rey, J.L. Merino, Rafael Peinado, Omer Berenfeld, José Jalife, José Millet et al. Spectral Analysis- Based Risk Score Enables Early Prediction of Mortality and Cerebral Performance in Patients Undergoing Therapeutic Hypothermia for Ventricular Fibrillation and Comatose Status. Int J Cardiol. 2015; 186:250-8. IF: 4.638 (Q1, D2).

2. Research projects and grants

Ongoing projects

• Title: “Exploring New Therapeutic Strategies in Hutchinson-Gilford Progeria Syndrome Preclinical Models (TREAT-HGPS)” Funding source: ERANET E-RARE-3 JCT -Instituto de Salud Carlos III. PI of working program 2: David Filgueiras. 2018-2021.
• Title: “In vivo high-resolution optical mapping as a powerful tool to study complex cardiac electrophysiology”. Funding source: Heart Rhythm Association (SEA) of the Spanish Society of Cardiology. PI: David Filgueiras. 2018-2019.
• Title: “Characterization of structural and dynamical wave propagation during atrial fibrillation: Correlation between pig models and human hearts from donors”. Ref: Funding source: Spanish Ministry of Economy and Competitiveness (ref. SAF2016-80324-R). PI: David 2017-2019.
• Title: “High-resolution optical mapping platform for isolated small animal hearts and tissue constructions”. Funding source: Spanish Ministry of Economy and Competitiveness (EQC2018- 005070-P). IP: José Jalife, (CNIC). Co-I: David Filgueiras. 2018-2019.
• Title:”Centro de Investigación en Red Enfermedades Cardiovasculares (CIBERCV)”.Funding Source: Instituto de Salud Carlos III (CB16/11/00458). PI: Julián Pérez-Villacastín. Co-I: David Filgueiras. 2017- 2019.
• Title: “Predictors in the Effective Termination of Paroxysmal Atrial Fibrillation through the Blockade of Atrial-specific Ionic Currents”. Funding Source: CARDIOME International AG and Pro-CNIC Foundation. IP: David Filgueiras. 2016-2019.

• Completed projects

• Title: “MRI-based 3D Modeling and Incorporation of Functional Properties for Accurate Characterization of Ventricular Tachycardia Circuits Associated with Established Myocardial Infarction in the Pig Animal Model”. Funding Source: Spanish Society of Cardiology. PI: David Filgueiras. 2014-2015.
• Title: “MRI-based 3D Modeling of Infarct-related Patient-Specific Fibrotic Substrates for Ventricular Tachycardia Ablation Guided Ablation”.Funding Source: Eugenio Rodríguez Pascual Foundation. PI: David Filgueiras. 2013 -2014.
• Title: “Circuit Characterization of Macroreentrant Ventricular Tachycardia (VT) by Activation Maps and Postpacing Intervals during VT, and by Activation and Stimulation during Sinus Rhythm”. Funding Source: Spanish Society of Cardiology. PI: David Filgueiras. 2013-2014.
• Title: “Simultaneous echocardiography and electrocardiography-based atrial electromechanical mapping during atrial fibrillation to predict effective pharmacological cardioversion”. Funding Source: Salud 2000 Foundation. PI: David Filgueiras. 2012-2019.
• Title: Ionic Mechanisms of Atrial Fibrillation. Funding Source: Jesús Serra Foundation. PI: David Filgueiras. 2015-2016.

3.  Contracts

• Title: “Spatial and temporal characterization of ventricular fibrillation and its relationship with the underlying 3D substrate”. Joint research agreement with the University Rey Juan Carlos (URJC). From 2016 to
• Title: “Study of complex cardiac activation during cardiac fibrillation from high-resolution optical mapping signals”. Joint research agreement with the University Politécnica de Valencia (UPV). From 2016 to
• Title: “Computational validation of 3D models to characterize scar transmurality from cardiac magnetic resonance images obtained in a pig model of myocardial infarction”. Joint research agreement with the University of Valladolid (UV). From 2015 to
• Title: “Magnetic resonance imaging-based 3D modeling of ventricular substrate for accurate characterization of in-vivo scar-related monomorphic ventricular tachycardia: Translational study from pigs to humans”. Research agreement with the Barcelona Supercomputing Center (BSC). From 2014 to date.

• Title: “Biological and computational characterization of mechanisms underlying paroxysmal and persistent atrial fibrillation in a pig model that resembles clinical progression of the arrhythmia”. Preclinical Research agreement with St. Jude Medical Spain. 2015-2019.
• Title: “Simultaneous echocardiography and electrocardiography-based atrial electromechanical mapping during atrial fibrillation to predict effective pharmacological cardioversion”. Master Research agreement with Philips Ibérica, (Philips Medical Systems). From 2015 to

4.  Patents

• Authors: Jorge García Quintanilla, David Filgueiras Rama, Nicasio Pérez Castellano y Julián Pérez Villacastín. Title: “Method for the identification of cardiac fibrillation drivers and/or the footprint of rotational activations using single optical or electrical signals without requiring simultaneous acquisition. Ref: 18382729.4 (European Patent Office). Date. 11 Oct, 2018.Owner: CNIC, Hospital Clínico San
• Authors: David Filgueiras Rama; Esteban Lópes de Sá Areses; José Millet Roig; Conrado Javier Calvo Saiz. Title: “Method of predicting or prognosticating neurological performance in patients who have suffered a cardiac arrest and optionally comatose status due to ventricular fibrillation”. Ref: 14382456.3 – 16572014 (European Patent Application). Date: 2014. Owner: CNIC, Hospital Universitario La Paz, Universidad Politécnica de

5.  Institutional responsibilities

• Member of the Innovation Advisory Board of CompBioMed project (https://wcompbiomed.eu/innovation/innovation-advisory-board/) financed by European Union Horizon 2020 Program (Grant agreement No 675451).
• Member of the research commission of the Hospital Clínico San
• Member of stakeholders´s group project CardioScape (European cardiovascular research landscape and recommendations for future research strategy).
• Organizer member International CNIC conference : “Atrial fibrillation: from mechanisms to population science”. Organizers: José Jalife, David Filgueiras, Miguel Manzanares & Stephan
• Director of the Animal Welfare Committee of Spanish Cardiovascular Research Center Carlos III (CNIC), Madrid, Spain.

6.  Memberships of scientific societies

Reviewer of the following scientific journals: Circulation Research; New England Journal of Medicine; Circulation; Journal of the American College of Cardiology; Circulation Arrhythmia & Electrophysiology; Heart Rhtyhm; Nature Communications; Frontiers in Physiology; Journal of Visualized Experiments; Archivos de Cardiología de Mexico; Revista Española de Cardiología; JACC Clinical Electrophysiology; Journal of Cardiovascular and Translational Research.

7.  Others merits

• Member of Scientific Societies: American Heart Association (AHA), Heart Rhythm Society (HRS), Sociedad Europea de Cardiología, (ESC), European Heart Rhythm Association (EHRA) y del Working Group on Cardiac Cellular Electrophysiology, Sociedad española de cardiología (SEC), Sección de electrofisiología y arritmias de la sociedad española de cardiología (SEA).
• Awards:

2014 (Dr. David Filgueiras): Annual outstanding doctoral dissertation award by the Universidad Autónoma de Madrid, Spain.

2012 Best Spanish Research Article in Cardiology (Dr. David Filgueiras), Royal Spanish Academy of Medicine, Spain.